CoupTFI Interacts with Retinoic Acid Signaling during Cortical Development

نویسندگان

  • Susan J. Harrison-Uy
  • Julie A. Siegenthaler
  • Andrea Faedo
  • John L. R. Rubenstein
  • Samuel J. Pleasure
چکیده

We examined the role of the orphan nuclear hormone receptor CoupTFI in mediating cortical development downstream of meningeal retinoic acid signaling. CoupTFI is a regulator of cortical development known to collaborate with retinoic acid (RA) signaling in other systems. To examine the interaction of CoupTFI and cortical RA signaling we utilized Foxc1-mutant mice in which defects in meningeal development lead to alterations in cortical development due to a reduction of RA signaling. By analyzing CoupTFI(-/-);Foxc1(H/L) double mutant mice we provide evidence that CoupTFI is required for RA rescue of the ventricular zone and the neurogenic phenotypes in Foxc1-mutants. We also found that overexpression of CoupTFI in Foxc1-mutants is sufficient to rescue the Foxc1-mutant cortical phenotype in part. These results suggest that CoupTFI collaborates with RA signaling to regulate both cortical ventricular zone progenitor cell behavior and cortical neurogenesis.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2013